We observed 32 patients with vasorenal hypertension; the balloon angioplasty of renal arteries was performed in all patients; in 5 cases with stenting of artery. The 24-hours monitoring of blood pressure (by Korotkov method), functional renal indices, ultrasonic investigation of heart, kidneys and renal arteries and angiography of renal arteries were carried out before and after balloon angioplasty, in 3, 6 and 12 months. Our study shows the opportunity and expediency of continuous wave Doppler (CWD) as a qualitative non-invasive method of diagnostical screening and may be of great value in assessment of results of renal arteries angioplasty. We observed a strong correlation between blood pressure gradients, getting from CWD, and results of direct intra-arterial blood pressure measuring during the angioplasty. The analysis of ultrasonographical findings revealed satisfactory hipotensive effect of renal artery angioplasty, which has sustained during one year of observation. The tendency to decrease of thickness of the interventricular septum and the inferior wall of left ventricle was marked. In patients with critical stenosis of renal arteries, complicated with renal functions insufficiency, after successful balloon angioplasty we observed significant increase of glomerular filtration, evaluated by clearance of endogenic creatinin. Also, we marked the augmentation of volumeric sizes of stenosis-related kidney in 12 months after angioplasty.

We examined 33 children with unilateral kidney diseases: hydronephrosis (10), hypoplasia (7) and other uronephrologic diseases. In 18 patients chronic pyelonephritis in a period of remission was diagnosed. In these patients following pathologic changes of contralateral kidney were revealed: high levels of 5-hydroxyeicozotetraenic acid and alkaline phosphataze, vasculitis of renal arteries (8 children), renal arterial hypertension (1 child). In 15 patients without chronic pyelonephritis pathologic changes of contralateral kidney were not revealed. Consequently patients with unilateral chronic pyelonephritis have to be examinated very carefully in departments specialized for angiological diagnostic procedures and treatment.

Experimental data concerning cytokine production dysfunction associated with nephrotic syndrome with minimal change are highly controversial. The insufficiency of interleikyne-10 (IL-10) which suppresses vascular permeability factor and many other anti-inflammatory cytokines secretion play an important role in the development of this condition. Data on disbalanced production of IL-10 in clinic are particularly insufficient. We conducted the direct measurements and analyzed IL-10 and IL-8 blood level in 7 children with steroid-sensitive nephrotic syndrome. The patient in the acute phase of the disease had the decreased down to 0.8 pg/ml IL-10 level. It increased up to 5 pg/ml (6 times) at the beginning of remission. IL-8 was not found in any patient with the remission period of steroid-sensitive nephrotic syndrome, IL-10 in 4 patients was higher normal. Thus the increased IL-10 production at the beginning of remission with its consequent normalization contributes to the elimination of T-lymphocytes dysfunction, IL-8 inhibition and promotes the active phase- remission period transition of the steroid-sensitive nephrotic syndrome.

Cytogenetic characteristic of children with kidney diseases is presented in the study. Chromosome abnormalities, frequency is considerably higher in children with ecological nephropathy than in healthy children. Cytogenetic examination of children with different forms of nephropathy from the Department of congestive and acquired kidney diseases of Institute of Pediatrics and Child Surgery was conducted as some sort of a control. Children included were from various regions of Russia without toxic metal pollution. Frequency of chromosome abnormalities in the control group turned out to be close to frequency in common population. This indicator could be used as a marker of nephropathy developing in people from regions polluted with toxic metals.