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Том 10 №2 2008 год - Нефрология и диализ

Матриксные металлопротеиназы в патогенезе острых и хронических заболеваний почек (Обзор литературы)


Бобкова И.Н. Козловская Л.В. Ли О.А.

Аннотация: Матриксные металлопротеиназы (ММП) (также называемые матриксинами) - семейство цинк-зависимых эндопептидаз, играющих ключевую роль в расщеплении компонентов экстрацеллюлярного матрикса (ЭЦМ), базальных мембран и ряда клеточных поверхностных белков. В физиологических условиях эти процессы необходимы для эмбрионального развития, морфогенеза, репродукции, тканевой резорбции, ангиогенеза, апоптоза и т. д. Изменение активности ММП (как увеличение, так и снижение) сопутствует многим заболеваниям человека (опухоли, фиброзирующие заболевания сердца, легких, печени и почек, артрит, язвенная болезнь желудка и т. д.). Настоящий обзор касается роли ММП в почечной патологии. Представлены последние сведения о локализации ММП и тканевых ингибиторов ММП (ТИМП) в структурах почки, анализируются нарушения в системе ММП/ТИМП при ряде острых и хронических заболеваний почек, определены возможные направления коррекции этих нарушений.

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Ключевые слова: матриксные металлопротеиназы, тканевые ингибиторы матриксных металлопротеиназ, ингибитор активатора плазминогена I типа, хронический гломерулонефрит, диабетическая нефропатия, острая почечная недостаточность, карцинома почки, ингибиторы АПФ, блокаторы рецепторов ангиотензина II

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