Cytokine and growth factors complex in children with vesico-ureteral reflux
Abstract
In order to reveal the role of cytokines and growth factors in renal scar formation in children with chronic pyelonephritis (CP) and vesico-ureteral reflux (VUR) 360 patients with impaired urodynamics aged from 5 to 15 years were examined. In all of them the 24 hours urine excretion of tumor necrosis factor (TNF-α), interleukins-1, -6, -8, -10 (IL-1, -6, -8, -10) and serum concentration of fibroblast growth factor (FGF), transforming growth factor-β (TGF-β), insulin-like growth factor-1 (IGF-1) have been measured by immunoenzime method. All the children underwent color Doppler ultrasound (CDUS) and nuclear examination of kidneys. Three groups of patients were determined: 1) with VUR and normal X-ray and ultrasound pictures of kidneys (n = 190); 2) with CDUS detected reflux nephropathy (RN) (n = 65); 3) with IVU confirmed reflux nephropathy (n = 85). Patients with CP without VUR (n = 20) were used as controls. As a result, all the patients demonstrated significantly elevated daily urine excretion of cytokines and serum concentration of growth factors in comparison with control (p < 0,05), that may reflect the protraction of covered inflammation in renal parenchyma in remission of CP. The similar dynamics of cytokines and growth factors profile in patients with X-ray confirmed RN and CDUS sings of renal scar formation suggestsing they can be used as early markers of renal tissue damage.
About the Authors
S. S. Paunova
РГМУ, НЦЗД РФ, МДКБ, г. Москва
Russian Federation
Russian Federation
A. G. Kucherenko
РГМУ, НЦЗД РФ, МДКБ, г. Москва
Russian Federation
Russian Federation
I. E. Smirnov
РГМУ, НЦЗД РФ, МДКБ, г. Москва
Russian Federation
Russian Federation
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Review
For citations:
Paunova S.S., Kucherenko A.G., Smirnov I.E. Cytokine and growth factors complex in children with vesico-ureteral reflux. Nephrology and Dialysis. 2005;7(4):435-439. (In Russ.)
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