Profiling of sodium and ultrafiltration at patients on a program hemodialysis: Focus on quality of life

The aim: to study the effect of sodium profiling and ultrafiltration on the quality of life of patients on program hemodialysis. Materials and methods of research: in the process of prospective clinical research, two groups of patients with terminal stage chronic kidney disease (CKD) were formed who received therapy with program hemodialysis (HD). Group I patients (n=54) received D-treatment on regulated profiles. Patients with comparison groups received hemodialysis therapy without considering profile-treatment regimens. The study assessed: the quality of life indicators using the SF 36 questionnaire, blood pressure, and laboratory indicators. The duration of the study was 12 months. Patients received HD treatment on Gambra machines with the Exalis system connected (automatic calculation of Kt/V, blood pressure measurement). Results: it was established that the profiling of sodium and ultrafiltration (using Profiles No. 3 and No. 5) in patients on program hemodialysis was a way of stabilizing blood pressure, positive dynamics of laboratory indicators, and was accompanied by an improvement in quality of life according to the questionnaire SF 36 on the scales of physical, role, social functioning, life activity, and psychological health. At the same time, a significant improvement in the indicators occurred in group I compared to the control group by scales: VT (life activity) (64.3±2.7 vs 54.2±4.2, p=0.0001), RE (role functioning due to emotional state) (64.1±3.3 vs 52.1±2.4, p=0.0001), SF (social functioning) (70.8±3.1 vs 65.5±2.5, p=0.0001) and MH (61.8±2.3 vs 55.4±1.6, p=0.0001). With sodium profiles and ultrafiltration, patients experienced an improvement in the physical and psychological components of health at the same time, which is very important from the standpoint of a personalized approach in medicine. Conclusions. Regulation of sodium profiling and ultrafiltration in patients on pro-gram hemodialysis allows for stabilizing blood pressure, achieving positive dynamics of laboratory indicators. When profiling sodium and ultrafiltration in patients on program hemodialysis along with improvement of somatic state there is an improvement of both physical and psychological component of health.

гемодиализ, профилирование натрия и ультрафильтрации, качество жизни, опросник SF 36, hemodialysis, sodium profiling and ultrafiltration, quality of life, SF 36 questionnaire

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