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Том 12 №1 2010 год - Нефрология и диализ

Риск прогрессирования стероид-резистентного нефротического синдрома у детей ассоциирован с малой массой тела при рождении

Приходина Л.С. Длин В.В. Игнатова М.С.

Аннотация: В работе представлены результаты ретроспективного 10-летнего наблюдения за течением стероид-резистентного нефротического синдрома у 65 детей, у 5 из которых отмечалась малая масса тела при рождении (<2500 г), обусловленная недоношенностью. У пациентов с малой массой тела при рождении в отличие от детей, рожденных с нормальной массой тела, установлен высокий относительный риск (ОР) быстрого снижения функций почек (СКФ >10 мл/мин/1,73 м /год), составляющий 2,53 (p < 0,05), и низкая пятилетняя почечная выживаемость (0 и 61%; р = 0,00084). Полученные результаты исследования свидетельствуют о влиянии малой массы тела при рождении на течение и прогноз стероид-резистентного нефротического синдрома у детей. Малая масса тела при рождении может рассматриваться в качестве фактора риска прогрессирования заболевания с быстрым снижением почечных функций.

Для цитирования: Приходина Л.С., Длин В.В., Игнатова М.С. Риск прогрессирования стероид-резистентного нефротического синдрома у детей ассоциирован с малой массой тела при рождении. Нефрология и диализ. 2010. 12(1):039-045. doi:

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Ключевые слова: дети, стероид-резистентный нефротический синдром, малая масса тела при рождении, прогрессирование, children, steroid-resistant nephrotic syndrome, low birth body weight, progression

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