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Том 25 №2 2023 год - Нефрология и диализ

Вторичный гиперпаратиреоз. Специфика, сложности, особенности лечения. Обзор литературы. Часть I

Шабунин А.В. Шутов Е.В. Долидзе Д.Д. Захарова Е.В. Слепухова Д.В. Кованцев С.Д. Большаков С.А.

DOI: 10.28996/2618-9801-2023-2-222-231

Аннотация: В представленном обзоре литературы освещены современные представления о патогенезе и актуальные вопросы медикаментозного лечения вторичного гиперпаратиреоза у больных с хронической болезнью почек. Факторами развития и прогрессирования вторичного гиперпаратиреоза считают наличие гипокальциемии, гиперфосфатемии и низкий уровень кальцитриола. На первых этапах лечения вторичного гиперпаратиреоза используется консервативный подход, который направлен на коррекцию каждого из этих факторов. В обзоре обобщен опыт использования фосфат-связывающих препаратов, витамина Д и его аналогов и кальцимиметиков у данной категории больных. Рассмотрены механизмы действия этих препаратов и представлены схемы лечения для достижения удовлетворительного контроля минерально-костного обмена и снижения рисков развития и прогрессирования тяжелого гиперпаратиреоза.

Для цитирования: Шабунин А.В., Шутов Е.В., Долидзе Д.Д., Захарова Е.В., Слепухова Д.В., Кованцев С.Д., Большаков С.А. Вторичный гиперпаратиреоз. Специфика, сложности, особенности лечения. Обзор литературы. Часть I. Нефрология и диализ. 2023. 25(2):222-231. doi: 10.28996/2618-9801-2023-2-222-231

Весь текст

Ключевые слова: хроническая болезнь почек, гемодиализ, вторичный гиперпаратиреоз, патогенез, фосфат-связывающие препараты, витамин D, кальцимиметики, паратгормон, околощитовидные железы, chronic kidney disease, hemodialysis, secondary hyperparathyroidism, pathogenesis, phosphate binders, vitamin D, calcimimetics, PTH, parathyroid gland

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